English publication

Stoelhorst, G.M.S.J., Martens, S.E., Rijken, M., van-Zwieten, P.H.T., Hofmeier, I., Roggeveen, H.C.J., Mourad-Baars, P.E.C., Theunissen, N.C.M., Verrips, G.H., Fekkes, M., Koopman, H.M., Zwinderman, A.H., Wit, J.M., & Veen, S. on behalf of The Leiden follow-up project on prematurity(2003). Quality of life in 1 year old preterm infants born before 32 weeks of gestational age. In: Stoelhorst, G.M.S.J. Development, Quality of Life and behavior at 2 years of age in very preterm infants. Ph.D. Thesis Leiden University Medical Center, The Netherlands: Drukkerijencombinatie Stramproy Weers bv. ISBN: 90-9016712-9, p.27-43

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Objective: To determine the effect of prematurity (GA<32 weeks) on Health Status (HS) and Health Related Quality of Life (HRQoL) at the corrected age of 12 months in a regionally defined, prospective cohort study.
Methods: The Leiden Follow-Up Project on Prematurity (LFUPP) includes all liveborn infants of <32 weeks in 1996 and 1997 (n=266). HS and HRQoL were prospectively measured using the TNO-AZL-Preschool-Quality of Life-questionnaire (TAPQOL) (completed by the parents) which has 10 scales for children aged 1-1.5 years. The TAPQOL-data of 51 term born children drawn from "Well-Baby-Clinics" were used as reference.
Results: We analyzed 172 TAPQOL's (73%) of 236 survivors. Median HS- and HRQoL-scores were maximal in the stomach-, lungs-, skin-, positive mood and liveliness-scale. Compared with the reference group, HS and HRQoL-scores were significantly lower in the stomach-, eating disorders and lungs-scale. Comparison within the study-group showed that lower GA 923-28 wks), bronchopulmonary dysplasia (BPD) and abnormal neurological outcome at term and at 12 months corrected age were associated with significantly lower HS- and HRQoL-scores in one or more of the eating-related scales: stomach, appetite and eating-disorders.
Conclusions: The majority of the premature infants had maximal HS and HRQoL-scores in 5 out of 10 scales at 12 months of corrected age. The eating related scales were most frequently reported as being unsatisfactory, both in comparison with a term reference group and in infants of lower GA, infants with BPD and infants with neurological abnormalities.


very premature infants, health status, health related quality of life

picture of N.C.M. Theunissen

Last updated on 12 February, 2015.